Cri-Du-Chat means “Cry of the cat” in French. It gets its name from its most characteristic hallmark feature in newborns were they comprise a very distinctive high-pitched, weak, mewing cat like cry during infancy caused by an abnormal development of the larynx that is usually diagnostic for the syndrome. This syndrome has many names to it as the Chromosome 5p- syndrome, Deletion 5p- syndrome, 5p minus syndrome, Cat cry syndrome, and Monosomy 5p but most commonly known as the Cri-Du-Chat Syndrome. Incidences of this disorder vary between 1 in every 20,000 – 50,000 live births worldwide and according to the 5p minus Society, approximately 50 to 60 children are born with cri du chat in the United States each year. Dr. Jerome Lejeune in 1963 described the disorder as a hereditary congenital syndrome linked to a partial deletion of the short arm, or p region in chromosome 5 but in %90 of patients the deletion is sporadic which means it could occur randomly and for it being just hereditary is just not the case.
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